Forum:Looking for Participants: Meenta NovaSeq RunShare Beta
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4.9 years ago

Hi Everyone,

I'm from a small Boston based company called Meenta, and we are launching a beta for our NovaSeq Runshare Program for a small cohort of users and hosts (think Uber Pool for NGS).

Initial versions will work like so: If you have a project coming up you can post and other researchers can find you. You can set your preferences for who you would share your flow cell with; internal to your university, read type, a specific flow cell type, number of samples etc.

Researchers can set their favorites so they get updated with new projects that match their watch parameters. When researchers are ready to share, we will have a ‘join’ and ‘invite’ process to allow the researchers to communicate. When a project is ready to go, they can choose a provider and submit a sample. Our core sample management features handle all the communications, shipping labels, tracking, and updates, as well as the split invoices, and data delivery.

But we need feedback on how best to help researchers find and share lanes, hence this beta project.

Apply here!

RunShare next-gen NovaSeq • 1.7k views
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Why would someone want to do this rather than send samples to a company/core and have them do the work of ensuring the flow cells are filled?

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Maybe cost and turnaround time is better?

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I guess that's their hope. We'll see what happens.

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Hi Devon, thanks for your question. In short, a lot of the companies/cores on the supplier side that we work with are academic cores where utilization rates of their instruments are generally low. They often don't have another project to run through at the same time which means the user eats the extra cost or has to wait even longer to get their data. When this is fully up and running the user will be able to book the RunShare on demand (as they currently can on our platform for a specific instrument/individual run - think of it as AirBnb for Genomic Sequencing).

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Interesting, well I hope it works out :)

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This would work only where a submitter is willing to start with samples not ready to run libraries. A core would be foolish to take a submitter at their own word, unless the participants are willing to share the cost of the MiSeq nano run (or perhaps your suppliers build that in) to check library compatibility.

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Good point! Some suppliers do build in the MiSeq Nano run into their runs already. Keep in mind though that the application will allow a submitter to find a run with the right read length, read type and indices etc...matched to a given NovaSeq run...like Uber Pool where all the riders are going to the same destination with the same requirements. Would welcome your input as we build out the app...

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You are assuming that users are going to have correct/provide right information. Seen too many people making errors with own metadata over the years :-) Very likely with index sequences.

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4.9 years ago
gabor ▴ 30

Having built and run a molecular diagnostic company under CLIA/CAP regulations we tend not to make these types of assumptions. However, you are correct there is no perfect system in science. Likewise, sample mixups by technicians in the lab could also happen...and not all cores do sample genotyping for this type of error but some cores do provide Meenta 2d barcoded tubes to mitigate some of this risk. It is also part of a larger question we are addressing in the field of implementing clear sample QC submission guidelines (which is already in the platform) across thousands of instruments (not just NGS) in our UI as well as pre-data delivery instrument and variant calling QC scores in collaboration with academia. That is, how can we "equalize" quality across thousands of instruments (and their associated services) and beyond as other platforms have done so well in the direct to consumer space? Last, if you could provide suggestions for how to incorporate into our Hosts processes methods like NGSCHeckmate we would welcome your input!

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some cores do provide Meenta 2d barcoded tubes

Interesting. So you intend to act as a full fledged clearing house for all samples going through your platform? So the billing/payment will also be through Meenta? I suppose you will add a surcharge during that process to make this economically viable? It may also work best for cores since they only need to worry about billing Meenta each month rather than tens of users/institutions across the world.

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"Clearinghouse", no. A global network of instruments that you can spin up in a few clicks like CPU time on AWS, yes! Yes, billing payment runs through Meenta. There are various ways to monetize the model, not just the transactions. And it is true cores don't have to waste their time on generating dozens of quotes and never seeing a project come through as all the pricing is visible. Meenta does not allow bookings to come through without a validated payment method on the user side. Does Amazon allow users to send pricing requests to suppliers? In many ways Life Sciences is still in the pre-internet age....multi-million dollar pieces of equipment and yet no one really knows where they are how to access them as a millennial would!

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4.9 years ago
gabor ▴ 30

"Clearinghouse", no. A global network of instruments that you can spin up in a few clicks like CPU time on AWS, yes! Yes, billing payment runs through Meenta. There are various ways to monetize the model, not just the transactions. And it is true cores don't have to waste their time on generating dozens of quotes and never seeing a project come through as all the pricing is visible. Meenta does not allow bookings to come through without a validated payment method on the user side. Does Amazon allow users to send pricing requests to suppliers? In many ways Life Sciences is still in the pre-internet age....multi-million dollar pieces of equipment and yet no one really knows where they are how to access them as a millennial would!

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