Question: No mutations or copy number alterations was detected in stage I of cancer
0
gravatar for nazaninhoseinkhan
9 months ago by
Iran, Islamic Republic Of
nazaninhoseinkhan410 wrote:

Dear all,

I found no mutations or copy number alterations in about %30 of my tumor samples (stage one of tumor).

Would you please tell me if it is strange?

have anybody faced with the same issue?

Regards

Nazanin

ADD COMMENTlink written 9 months ago by nazaninhoseinkhan410
3
gravatar for German.M.Demidov
9 months ago by
Tübingen
German.M.Demidov1.8k wrote:

No mutations is indeed strange. Do you use panel sequencing?

1) tumor may be driven by epigenetic changes 2) mutations may be located outside of targeted regions 3) purity of the biopsy may be too low 4) other structural variants such as fusions may drive cancer

ADD COMMENTlink written 9 months ago by German.M.Demidov1.8k
1

Thank you so much for the explanation

ADD REPLYlink written 9 months ago by nazaninhoseinkhan410
1

Check out this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395/ - it is not about alternative mechanisms, but more about how many important mutations you may find for Different tumor types

ADD REPLYlink written 9 months ago by German.M.Demidov1.8k

Sure, thank u German

ADD REPLYlink written 9 months ago by nazaninhoseinkhan410

If an answer was helpful, you should upvote it; if the answer resolved your question, you should mark it as accepted. You can accept more than one answer if they all work.

Upvote|Bookmark|Accept

ADD REPLYlink written 9 months ago by RamRS30k
1

being honest I don't like my answer - it does not go into details and is partially contradictive with well-accepted theories such as "epigenetic changes are a consequence of genomic changes" - so it is usually considered as non-driving event, that's why I wrote it as a comment in the beginning. I also feel the list is not full. I'd wish more people contribute to this question - I'd also like to read the full and well-motivated list.

E.g. here is the mutational burden per cancer type - https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0424-2/figures/2 - but this is only a part of the answer

ADD REPLYlink modified 9 months ago • written 9 months ago by German.M.Demidov1.8k
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