Question: Down regulated genes in sC-RANseq
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gravatar for rob.costa1234
8 months ago by
rob.costa1234250
United States
rob.costa1234250 wrote:

In single cell RNAseq do we also list down regulated genes as key signature genes of a particular cell type? Thanks.

rna-seq • 154 views
ADD COMMENTlink written 8 months ago by rob.costa1234250

All analysis serves to your project goal. It all depends on what information you are trying to extract, and whether it is required for supporting your hypothesis.

ADD REPLYlink written 8 months ago by shoujun.gu310

You certainly can, people just tend to show those upregulated in a given cell-type/cluster, as it's arguably easier to interpret.

ADD REPLYlink written 8 months ago by jared.andrews076.8k

I agree. Also keep in kind that a gene being downregulated means it is upregulated a celltype you compared it with. Presentation of genes being up- or downregulated should imho be based on the message you want to send. If it makes more sense to report downregulated genes I see no reason not to do it. There is definitely no rule that forbids it. Whatever floats your boat :)

ADD REPLYlink written 8 months ago by ATpoint38k
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