Question: Down regulated genes in sC-RANseq
gravatar for rob.costa1234
6 weeks ago by
United States
rob.costa1234200 wrote:

In single cell RNAseq do we also list down regulated genes as key signature genes of a particular cell type? Thanks.

rna-seq • 97 views
ADD COMMENTlink written 6 weeks ago by rob.costa1234200

All analysis serves to your project goal. It all depends on what information you are trying to extract, and whether it is required for supporting your hypothesis.

ADD REPLYlink written 6 weeks ago by shoujun.gu280

You certainly can, people just tend to show those upregulated in a given cell-type/cluster, as it's arguably easier to interpret.

ADD REPLYlink written 6 weeks ago by jared.andrews075.0k

I agree. Also keep in kind that a gene being downregulated means it is upregulated a celltype you compared it with. Presentation of genes being up- or downregulated should imho be based on the message you want to send. If it makes more sense to report downregulated genes I see no reason not to do it. There is definitely no rule that forbids it. Whatever floats your boat :)

ADD REPLYlink written 6 weeks ago by ATpoint30k
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