Down regulated genes in sC-RANseq
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22 months ago
rob.costa1234 ▴ 290

In single cell RNAseq do we also list down regulated genes as key signature genes of a particular cell type? Thanks.

rna-seq • 301 views
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All analysis serves to your project goal. It all depends on what information you are trying to extract, and whether it is required for supporting your hypothesis.

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You certainly can, people just tend to show those upregulated in a given cell-type/cluster, as it's arguably easier to interpret.

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I agree. Also keep in kind that a gene being downregulated means it is upregulated a celltype you compared it with. Presentation of genes being up- or downregulated should imho be based on the message you want to send. If it makes more sense to report downregulated genes I see no reason not to do it. There is definitely no rule that forbids it. Whatever floats your boat :)

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