I was wondering what others think about this not really new development, but at least newer implementation of Read Until for Oxford Nanopore sequencers (preprint https://www.biorxiv.org/content/10.1101/2020.02.03.926956v2.full.pdf+html and Github repo https://github.com/LooseLab/ru .
We have a MinION sequencer but haven't used it much. This might be a game changer if it could potentially be used to do target enrichment of exons and perhaps previously identified ddRAD loci for non-model species without having to synthesize expensive RNA baits for target enrichment. Given the translocation speed of 100s of bases per second through the nanopores, it seems like this might not work as it promises as hundreds of bases would be read before any decision can be made to reject the DNA fragment- just my thoughts.
What do others think? Any hands-on experiences?