How could I compare two Gene interaction Networks?
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12 months ago
Wox ▴ 450

What are the possible ways that I could compare two Gene interaction Networks?

WT upregulated genes interaction network vs Mutants upregulated genes interaction network

rna-seq genome gene • 243 views
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To some extent, it depends on what you're interested in. What biological question(s) are you trying to address?

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Few things you can compare:
- genes with top degrees across the two networks (+ other network metrics)
- the functional enrichment of the gene modules that you believe can be interesting
- functional enrichment of the interactors of the DE genes
As a general rule, focus on genes in the pathways you're interested in.

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