I used GATK's Funcotator to annotate a VCF file I have and it produced a MAF file just over 2GB in size. I've tried using pandas in Python and maftools in R and it hasn't worked. Specifically the file size seems to be too large to be opened in R throwing this error
Error in data.table::fread(file = maf, sep = "\t", stringsAsFactors = FALSE, : File '' does not exist or is non-readable.
and pandas isn't really made for MAF files. Usually when running this annotation it was enough to open it in Excel but this file is way too big. Does anybody know an application or package (whether it be R or python or something else) to open MAF files of this size? Any help is appreciated.