I'm new to this forum so I hope this question is suitable. I don't understand the difference between a GWA (genome wide association study) and a GWLS (genome wide linkage study). I'm a computer scientist having to brush up biology!
Here is my basic understanding (in case I have any unhelpful misconceptions): GWA: hundreds/thousands of individuals with and without a specific phenotype are genotyped to see which loci if any are statistically associated with the phenotype
linkage studies: I've seen linkage studies used for genetic mapping and to indentify loci associated with disease. In the later you measure markers and trait values in families and see which segregate similarly to identify the underlying loci of the disease. I've never looked at math.
What is a GWLS and how is it different than a linkage study? I cant find a basic definition and the research papers on the subject are too advanced for me. What does a GWLS tell you that a GWA doesn't tell you? Or maybe the 2 methods are complementary but suitable under different circumstances. Linkage analysis to me implies breeding and I'm not sure its ethical to breed human beings yet :)
thanks for your time