Question: Which Measures Of Node Centralities Can Be Applied To A Biological Network?
6
gravatar for Giovanni M Dall'Olio
9.1 years ago by
London, UK
Giovanni M Dall'Olio27k wrote:

Node Centralities are parameters that, given a node's position and connections, indicate its importance within a network. The simplest example of node centrality is the degree, which is the number of edges connected to a node; but there are a lot of other ways to measure node centrality, for example betweenness, stress, closeness, centroid, etc..

How many measures for node centralities do you know, that could be applied to a biological network? Can you recommend a good review of reference to compare these measures, and their meaning in a biological context?

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ADD COMMENTlink written 9.1 years ago by Giovanni M Dall'Olio27k
2
gravatar for Giovanni M Dall'Olio
9.1 years ago by
London, UK
Giovanni M Dall'Olio27k wrote:

I'll put some answers to get this discussion started.

  • The Wikipedia page describes 4 node centrality measures: Degree, Betweenness, Closeness and Eigenvector.

  • I like the description of different Node Centrality measures in the supplementary materials of the paper for Centiscape, a plugin for Cytoscape. There are good description of the possible biological meanings of each measure

  • a tool called CentiBin can calculate various measures of Node Centralities. Its documentation and its related publication are a good source to be started.

ADD COMMENTlink written 9.1 years ago by Giovanni M Dall'Olio27k

Nice collection of links

ADD REPLYlink written 9.1 years ago by Istvan Albert ♦♦ 83k
2
gravatar for Larry_Parnell
9.1 years ago by
Larry_Parnell16k
Boston, MA USA
Larry_Parnell16k wrote:

Here is what I can offer from someone who once gave me advice for a similar question:

Here are some topological graph measures that you may find useful. The more commonly used measures are at the top.

ADD COMMENTlink modified 7 months ago by RamRS26k • written 9.1 years ago by Larry_Parnell16k
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