Question: Can I Write A Research Paper Based On The Results Of Comparing Computational Predictions Of Two Proteins
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gravatar for Lavanya
5.9 years ago by
Lavanya50
chennai
Lavanya50 wrote:

I have modelled a membrane protein using Insight-2 and glide's-prime. In insight - 2 I have modelled the whole protein, whereas in glide-prime I modeeled only a particular region. can I communicate this work as a comparison of prediction by these 2 methods? or can anyone suggest how I can frame these 2 works and send for publication in journal

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ADD COMMENTlink modified 5.9 years ago by justinhaselbach250 • written 5.9 years ago by Lavanya50
3

See also: Do you know any outer membrane protein which do not have a beta-barrel structure?

I am not sure what the requirements are for getting papers on protein models accepted, but sometimes the best way to find out might be to actually submit a paper. Personally, I would be a bit skeptical about a model without any experimental validation. So, if you could get or find some experimental data or known structure to compare your model with that might improve things, though I heard getting crystal structure of membrane proteins is harder than other proteins. Also, why don't you make a full model from both programs. The way you are describing it now sound as if the models are not really comparable.

ADD REPLYlink modified 5.9 years ago • written 5.9 years ago by Michael Dondrup45k
1
gravatar for justinhaselbach
5.9 years ago by
United States
justinhaselbach250 wrote:

You MUST Publish if the following are true-

  1. Similar data-sets have been published in 'some journal'. !
  2. The study is enough IN-DEPTH.
  3. There is NOVEL information available after your study on the protein's- structure, function or similar aspects.
  4. And yes, DATA without analyses and biological significance is a "house of bricks and NOT home" !

Good to be in touch with a biologist, to be able to find out more on this as well.

Thanks,

ADD COMMENTlink written 5.9 years ago by justinhaselbach250
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