Question: How To Find Hydrophobic And Hydrophilic Regions In Protein?
1
gravatar for vibhanim.21
5.8 years ago by
vibhanim.2140
Manipal University
vibhanim.2140 wrote:

I have a protein. I want to analyse whether the tryptophan and tyrosin molecules fall in hydrophobic or hydrophilic region of my protein. please can anybody help me in this?

software analysis protein • 10k views
ADD COMMENTlink modified 4 months ago by Biostar ♦♦ 20 • written 5.8 years ago by vibhanim.2140
1
gravatar for justinhaselbach
5.8 years ago by
United States
justinhaselbach250 wrote:

May be a KYTE DOOLITTLE HYDROPATHY PLOT will help solve your problem- if it is integrated to the tools you use for protein analysis/ visualization. However many are free to use and available through a divergent web servers:

1.http://web.expasy.org/protscale/ 2. http://www.ibi.vu.nl/programs/scoobywww/ 3. http://bioinf.cs.ucl.ac.uk/psipred/ 4. http://mobyle.rpbs.univ-paris-diderot.fr/cgi-bin/portal.py?form=HCA#welcome 5. http://gcat.davidson.edu/DGPB/kd/kyte-doolittle.htm 6. http://www.vivo.colostate.edu/molkit/hydropathy/index.html

and so on !

Thanks,

ADD COMMENTlink written 5.8 years ago by justinhaselbach250
0
gravatar for aravind ramesh
5.8 years ago by
India
aravind ramesh500 wrote:

Calculate PSA(Percent solvent accessibility) values for the residues, It only works when you have structure of a protein. Otherwise(only sequence is available), then Trp and tyr are considered as hydrophobic, check for enrichment of charged and hydrophobic residues neighbouring these residues.

Hope this helps.

ADD COMMENTlink written 5.8 years ago by aravind ramesh500
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