Question: Meta-Analysis In Metal; Heterogeneity Test
gravatar for Joey
7.1 years ago by
Joey410 wrote:

Hi All,

I am using METAL for meta-analysis of some specific SNPS (6 SNPs of interest) across three studies. From the within study results, I can see that results from two of the studies are in the same direction while the results from the 3rd study is null.

When I use the "analyze heterogeneity" option in METAL, all the 6 SNPs are significant but the HtPVal for all is < 0.05. Does that mean it's not replicating? What are the consequences of this result?

Thanks a ton in advance,


gwas • 3.0k views
ADD COMMENTlink modified 7.1 years ago by Eric Normandeau10k • written 7.1 years ago by Joey410
gravatar for Fabio Marroni
7.1 years ago by
Fabio Marroni2.6k
Fabio Marroni2.6k wrote:

Not an expert in meta-analysis, but lack of homogeneity requires that different models of meta-analysis are carried out. You might give a look to this paper:

ADD COMMENTlink written 7.1 years ago by Fabio Marroni2.6k
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