Question: Meta-Analysis In Metal; Heterogeneity Test
0
gravatar for Joey
6.8 years ago by
Joey410
Seattle
Joey410 wrote:

Hi All,

I am using METAL for meta-analysis of some specific SNPS (6 SNPs of interest) across three studies. From the within study results, I can see that results from two of the studies are in the same direction while the results from the 3rd study is null.

When I use the "analyze heterogeneity" option in METAL, all the 6 SNPs are significant but the HtPVal for all is < 0.05. Does that mean it's not replicating? What are the consequences of this result?

Thanks a ton in advance,

Joey

gwas • 2.8k views
ADD COMMENTlink modified 6.8 years ago by Eric Normandeau10k • written 6.8 years ago by Joey410
0
gravatar for Fabio Marroni
6.8 years ago by
Fabio Marroni2.6k
Italy
Fabio Marroni2.6k wrote:

Not an expert in meta-analysis, but lack of homogeneity requires that different models of meta-analysis are carried out. You might give a look to this paper: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069930

ADD COMMENTlink written 6.8 years ago by Fabio Marroni2.6k
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