I am using METAL for meta-analysis of some specific SNPS (6 SNPs of interest) across three studies. From the within study results, I can see that results from two of the studies are in the same direction while the results from the 3rd study is null.
When I use the "analyze heterogeneity" option in METAL, all the 6 SNPs are significant but the HtPVal for all is < 0.05. Does that mean it's not replicating? What are the consequences of this result?
Thanks a ton in advance,