Question: Over Representation Vs Enrichment Analysis
1
gravatar for jack
4.0 years ago by
jack390
jack390 wrote:

Hi everyone,

would someone explain me what is the difference between representation vs enrichment analysis of genes ? is there any book or paper to read about these in more details ?

ADD COMMENTlink modified 9 weeks ago by shinobee20 • written 4.0 years ago by jack390
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It's the same thing really. I write a blog post about enrichment analysis recently: http://blog.nextgenetics.net/?e=94

ADD REPLYlink written 4.0 years ago by Damian Kao14k
1

FWIW: representation is just whether it is there or not. over-representation is the same as enrichment which means that, say you are working with genes, several genes from the same pathway are highly expressed or even several genes from the same pathway are diffenrentially expressed comapring two samples. In contrast, representation would than mean that genes are expressed but in no certain / specific manner.

ADD REPLYlink written 4.0 years ago by Phil S.630
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They're the same thing.

ADD REPLYlink written 4.0 years ago by Devon Ryan74k
1
gravatar for shinobee
9 weeks ago by
shinobee20
shinobee20 wrote:

Over- representation methods compare sets of genes annotated to pathways to a list of those genes that are significantly deferentially expressed (DE) between two phenotypes. Enrichment methods employ a “soft” version of over-representation based on a summary statistic to characterize the level of differential expression of genes in the pathway relative to a null distribution.

ADD COMMENTlink written 9 weeks ago by shinobee20
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