fgsea leading edge genes
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11 weeks ago

I'm using fgsea to find enriched genes/pathways. The returned leading edges contain many overlapping genes, which I understand. What I don't understand is that many seem to be in the same order. Are the leading edges arranged by significance?

E.g.

 [1] "RPLP0"  "RPS2"   "RPL28"  "RPS17"  "RPL13A" "RPL4"   "RPS8"   "RPL39"  "RPL32"  "RPS18"  "RPS19"  "RPS16" 
[13] "RPSA"   "RPL8"   "RPS23"  "RPLP1"  "RPL24"  "RPL19"  "RPL27A" "RPS5"   "RPL37A" "RPL34"  "RPS29"  "RPL3"  

Can I assume that RPLP0 is the "top" gene in this leading edge? Or is the order arbitrary?

gsea leading edge • 135 views
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