Hi Saran, I know of two companies that are or were (not sure which) working on this type of problem. One was Coda Genomics (now defunct) but you can look up Rick Lathrop. And the second is Perkin Elmer. I believe they both have patents as well. I believe that RL's patent uses thermodynamic calculations to determine the 'best' codon sequence while PE's uses melting point. Very interesting ideas.
Q. May I ask what you have found out, if anything? M