Question: an introduction to GO annotations
0
gravatar for Affan
4.2 years ago by
Affan290
Canada
Affan290 wrote:

I have the mouse genome split into 1000 bp bins. For each bin, I'd like to know how far is it from the nearest gene. A question I posted yesterday got the answer of using biomart (and its R package biomaRt). Going through biomart, I am a bit confused about the GO ontology terms: Consider the following diagram:

Consider a particular gene, with a particular transcript:

 

Why would a particular protein have so many GO terms? I am a math major and never really got introduced to GO ontology so if someone could explain this to me? I understand the terms as they are defined on http://geneontology.org/page/ontology-documentation but I am not sure why a particular protein would require so many terms.

 

 

gene ontology • 1.2k views
ADD COMMENTlink modified 4.2 years ago by Reema Singh150 • written 4.2 years ago by Affan290
1
gravatar for Reema Singh
4.2 years ago by
Reema Singh150
United Kingdom
Reema Singh150 wrote:

Hello Affan

Here's the description Go Terms -- Is It Normal To Have Multiple Go Terms Associated With A Specific Gene/Locus?

ADD COMMENTlink written 4.2 years ago by Reema Singh150

Good find, figures that I've answered a question like this before. In particular, the answer from justinhaselbach is useful, since it emphasizes the fact that a single gene can produce proteins with multiple functions, locations, and modes of action in different (or even the same) contexts.

ADD REPLYlink modified 4.2 years ago • written 4.2 years ago by Devon Ryan90k
0
gravatar for Pierre Lindenbaum
4.2 years ago by
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum120k wrote:

as far as I can see your screen show all the ancestors of only a few GO term : e.g: cytoplasm is_part_of_a cell  is_a cellular_component

ADD COMMENTlink written 4.2 years ago by Pierre Lindenbaum120k
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