histone modification and DNA methylation in gene regulation ?
3
0
Entering edit mode
6.8 years ago
yinzl2007 ▴ 20

The epigenetic includes histone modification and methylation and so on, and the epigenetic data can play some role on the gene regulation. I have seen some papers about the about the histone modification data play a role in gene regulation network, but I haven't seen many papers about the research on methylation on gene regulation ( on site level, not the genome wide ).

So what is the difference between histone modification and methylation in research of GRN? Or could you recommends some papers about the methylation on gene expression?

DNA-methylation histone-modification • 1.8k views
ADD COMMENT
1
Entering edit mode
6.8 years ago
jotan ★ 1.2k

Please also keep in mind that Promoter methylation and gene body methylation are not the same thing.

Promoter methylation generally indicates the gene is silenced.

Gene body methylation generally correlates with active transcription.

Methylation is thought to prevent transcription initiation. People sometimes get sloppy when discussing DNA methylation.

ADD COMMENT
0
Entering edit mode

Thanks for your reply. That's the first time I know the difference between promoter and the gene body actually.

ADD REPLY
0
Entering edit mode
6.8 years ago

There are a bunch of papers looking at site-specific methylation changes in the glucocorticoid receptor (that has a number of psychological effects). Just search pubmed for that for a number of examples.

ADD COMMENT
0
Entering edit mode
6.8 years ago
EagleEye 7.3k

There are tons of papers you just have to search.

Example: this is recent concept on methylation and gene expression

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00316-X

ADD COMMENT

Login before adding your answer.

Traffic: 1096 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6