I have some RNA-seq data from an unusual biological system, and as a result I need to look for genes that are differentially expressed genes between two samples, one of which was super stressed. My DESeq2 results said that more than 70% of genes had an adjusted p-value below 0.1! I was expecting a lot of differentially expressed genes, but this seems very high. Is there such a thing as 'too many' DEGs? Is there a way I can test whether my data fall into this category? Does anyone know of any solutions to this issue? Thanks in advance!