Question: MAF vs VAF
2
gravatar for lauren.wahyudi
12 months ago by
lauren.wahyudi20 wrote:

Hi all.. Anyone can help explaining the difference between MAF (mutant allele) and VAF (variant allele) frequency? Thanks

sequencing • 1.7k views
ADD COMMENTlink written 12 months ago by lauren.wahyudi20
3

Could be Multiple Ambiguous Formats ...

ADD REPLYlink modified 12 months ago • written 12 months ago by grant.hovhannisyan1.4k
1

As far as I know the 'M' in MAF means minor and not mutant. I think VAF and MAF are the same.

ADD REPLYlink written 12 months ago by WouterDeCoster37k
2

Note that even "minor allele frequency" is overloaded here. In a traditional sense, minor allele frequency refers to the frequency of an allele in a population of patients from a germline sampling. The variant allele frequency is typically used in a cancer setting to describe the proportion of reads with the variant allele within a single patient. The best option is to define what you mean very specifically; use in the literature is not a good guide, as is evidenced by the comments here.

ADD REPLYlink modified 12 months ago • written 12 months ago by Sean Davis25k

Yes, and I would favour the term Variant Allele Fraction (or Variant Allelic Fraction) rather than Variant Allele Frequency for this reason too!

ADD REPLYlink written 12 months ago by Len Trigg1.2k
1

Looks like the MAF acronym is being repeatedly hijacked!

There is:

  • MAF, minor allele frequeny
  • MAF, mutation annotation format
  • MAF, mutant allele fraction

Edit: As per Wouter's ultimate conclusion, you can consider mutant allele fraction and VAF as the same. Minor allele frequency is more used in GWAS studies.

ADD REPLYlink modified 12 months ago • written 12 months ago by Kevin Blighe39k
1

Don't forget the Multiple Alignment Format.

ADD REPLYlink written 12 months ago by kloetzl1.0k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1966 users visited in the last hour