Forum:10 Most important topic in Human evolutionary genomics
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5.2 years ago
aloke205 ▴ 40

Update: My presentation is complete. Thank you @jrj.healey, @Vitis, @Luiz and @grant.hovhannisyan for your suggestion because I got all positive comments :)

I want to explore more on this topic and write review article on this. If biostar members have some more ideas to add please do suggests me..

Thanks in advance

Original post:

I want to give presentation on Human evolutionary genomics in context of human diseases. As I am new to this field, till now I have prepared only about basic population genomic analysis like Tajima's D and codeml. But want to include some more interesting topic to make my presentation bit interesting .

Topic suggested by Biostars members:

  1. Mitochondrial Eve hypothesis (suggested by jrj.healey)
  2. How much such diseases is a product of time? or...how old they are? or...how 'modern' or 'new' or 'better' we are? (Suggested by Luiz)
  3. How neutral evolution and selective force shape human evolution (Suggested by Vitis)
  4. Ancient DNA studies and how they transformed our views in human evolution. There are plenty of recent high profiles papers on this topic. Also you can maybe talk about cultural traits like language, lifestyle (agriculturalism, hunting-gathering, etc), patriotically, and others, and how they impact out genomic composition (Suggested by grant.hovhannisyan)

Please suggests

evolutionary-genomics evolutionary-medicine • 1.6k views
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One topic I always find fascinating is how neutral evolution and selective force shape human evolution (actually a wider scope is for all evolution)? First, there is the methodology question of how we detect selection at the sequence/SNP/haplotype/population level. Then there is the more general question: which played (is playing?) a bigger role, neutral evolution or selection?

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One very hot topic in human evolutionary genomics is ancient DNA studies and how they transformed our views in human evolution. There are plenty of recent high profiles papers on this topic.

Also you can maybe talk about cultural traits like language, lifestyle (agriculturalism, hunting-gathering, etc), patriotically, and others, and how they impact out genomic composition.

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If its specifically about human evolutionary analyses, the obvious one would be how the Mitochondrial Eve hypothesis has been used (and subsequently thrown in to question).

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Thank you. Yes my presentation is specifically about human evolutionary analysis :)

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A suggestion. List topics you currently have in original post. That way people can see what you have at a glance without having to read every comment in this thread. Keep updating the list once you hit a new topic. If you need 10 then you seems to have a long way to go.

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I think is always nice create a link between the modern men and our ancestors. For example: there is many studies available in pubmed where they analyze some diseases related to genetic variations that was present in the past, such as diabetes, hypertension and cancer. The idea is: how much such diseases is a product of time? or...how old they are? or...how 'modern' or 'new' or 'better' we are?

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Can more information be added to this topic ???

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