Question: proteome data analysis
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gravatar for aswanikrishnap1994
11 months ago by
aswanikrishnap199410 wrote:

**i have 2 samples A & B proteome data analyzed using progenesis software. i have max fold change reported to be infinity. How will i convert these fold change to log2fc values for heat map generation?

data analysis proteomics • 282 views
ADD COMMENTlink modified 11 months ago • written 11 months ago by aswanikrishnap199410
1

From a mathematical point, log(Inf) = Inf.

ADD REPLYlink written 11 months ago by Jean-Karim Heriche22k

biologically these are significant proteins which are unique to one particular sample

ADD REPLYlink written 11 months ago by aswanikrishnap199410

If you don't want/can't use Inf, you need to come up with a replacement value. For visualization purposes, I guess any value that's higher than the max of the rest of the data could do. What to do really depends on what you want to achieve.

ADD REPLYlink written 11 months ago by Jean-Karim Heriche22k

You posted this as a Forum. I have changed it to a Question.

ADD REPLYlink written 11 months ago by Kevin Blighe60k
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