Question: proteome data analysis
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gravatar for aswanikrishnap1994
5 days ago by
aswanikrishnap19940 wrote:

**i have 2 samples A & B proteome data analyzed using progenesis software. i have max fold change reported to be infinity. How will i convert these fold change to log2fc values for heat map generation?

data analysis proteomics • 73 views
ADD COMMENTlink modified 5 days ago • written 5 days ago by aswanikrishnap19940
1

From a mathematical point, log(Inf) = Inf.

ADD REPLYlink written 5 days ago by Jean-Karim Heriche19k

biologically these are significant proteins which are unique to one particular sample

ADD REPLYlink written 5 days ago by aswanikrishnap19940

If you don't want/can't use Inf, you need to come up with a replacement value. For visualization purposes, I guess any value that's higher than the max of the rest of the data could do. What to do really depends on what you want to achieve.

ADD REPLYlink written 5 days ago by Jean-Karim Heriche19k

You posted this as a Forum. I have changed it to a Question.

ADD REPLYlink written 5 days ago by Kevin Blighe43k
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