Hello. I need to analysis mostly human whole exomes and far less frequently human whole genomes. And today, I must choose what is better for these purposes - 2x480 SSD or 2x2TB HHD. The current pipeline for exome analysis is very old and is written in Perl. And I'm going to rewrite it with new software. Please, help me to choose what kind of storage do I need for my goals. Also, this hardware will be used for six months.
Interestingly, there's a whole paper about this! https://academic.oup.com/bib/article/17/4/713/2240499/
It looks like some programs sped up significantly, others had no improvement. Personally I'd rather go for space than for speed (so the 2x2TB HDD), but I work with massive plant genomes, I don't know what scale of data you will be working with!