Question: Drug resistant vs. Drug sensitive data retreival from TCGA
0
gravatar for fawazfebin
11 days ago by
fawazfebin0
fawazfebin0 wrote:

Hi Can anyone guide me on how to retrieve drug resistant and drug sensitive patient data from the TCGA database ? Great thanks in advance.

ADD COMMENTlink modified 11 days ago by Kevin Blighe51k • written 11 days ago by fawazfebin0
4
gravatar for Kevin Blighe
11 days ago by
Kevin Blighe51k
Kevin Blighe51k wrote:

To get you started, please take a look at my previous answers:

You should be able to infer (from the available clinical data) the patients who relapsed while taking therapeutic agents.

Kevin

ADD COMMENTlink written 11 days ago by Kevin Blighe51k
2

Kevin is right, but I think you need to be able to make sure that you are careful about making sure that you understand the metadata.

For example, I think the clinical data is usually after the 1st bio-specimen collection. So, if you were looking for pre-existing changes (before treatment), then that could be an issue. In other words, you might need to be careful about think whether gene expression changes are pre-treatment or post-treatment (and whether patients have had multiple drugs and/or multiple follow-ups, etc.).

ADD REPLYlink modified 11 days ago • written 11 days ago by Charles Warden7.4k
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