Question: Drug resistant vs. Drug sensitive data retreival from TCGA
gravatar for fawazfebin
11 days ago by
fawazfebin0 wrote:

Hi Can anyone guide me on how to retrieve drug resistant and drug sensitive patient data from the TCGA database ? Great thanks in advance.

ADD COMMENTlink modified 11 days ago by Kevin Blighe51k • written 11 days ago by fawazfebin0
gravatar for Kevin Blighe
11 days ago by
Kevin Blighe51k
Kevin Blighe51k wrote:

To get you started, please take a look at my previous answers:

You should be able to infer (from the available clinical data) the patients who relapsed while taking therapeutic agents.


ADD COMMENTlink written 11 days ago by Kevin Blighe51k

Kevin is right, but I think you need to be able to make sure that you are careful about making sure that you understand the metadata.

For example, I think the clinical data is usually after the 1st bio-specimen collection. So, if you were looking for pre-existing changes (before treatment), then that could be an issue. In other words, you might need to be careful about think whether gene expression changes are pre-treatment or post-treatment (and whether patients have had multiple drugs and/or multiple follow-ups, etc.).

ADD REPLYlink modified 11 days ago • written 11 days ago by Charles Warden7.4k
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