Sequencing is not everything and can only take us so far. I would appreciate the development of systems that can freeze-capture cells in a time-course, and, through this, develop 3-dimensional images of chromatin and other cellular organelles, proteins, mRNA, etc. This can likely only be be achieved via electron microscopy or nuclear magnetic resonance (NMR), but could be linked up to sequencing data, including single cell RNA-seq, single cell DNA-seq, and single cell proteomics.
With just sequencing data itself, and with extremely powerful compute resources, it should actually be possible to model chromatin formation from whole genome sequence, but this would involve input from those working in, e.g., quantum chemistry (where I briefly worked). 3C, 4C, 5C, and Hi-C, etc., cannot really do this to a great extent.
Apart from this, we have already accumulated vast amounts of information and should be doing a lot better in terms of reducing mortality from chronic diseases. In a few areas, we have seemingly learned nothing... there are certain barriers, still, toward making research truly translational. More funding for SMEs could help, as these may have fresh ideas that the larger organisations struggle to find.