Forum: Interpretation Of Genomic Variants Using A Unified Biological Network Approach
gravatar for AndreiR
7.6 years ago by
São Paulo
AndreiR260 wrote:

Just sharing a interesting paper.

"Here we integrate the diverse modes of gene interactions (regulatory, genetic, phosphorylation, signaling, metabolic and physical protein-protein interactions) to create a unified biological network. We then exploit the unique properties of loss-of-function tolerant and essential genes in this unified network to build a computational model that can predict global perturbation caused by deleterious mutations in all genes."

Citation: Khurana E, Fu Y, Chen J, Gerstein M (2013) Interpretation of Genomic Variants Using a Unified Biological Network Approach. PLoS Comput Biol 9(3): e1002886. doi:10.1371/journal.pcbi.1002886 Editor: Andrey Rzhetsky, University of Chicago, United States of America Received: September 26, 2012; Accepted: November 30, 2012; Published: March 7, 2013

ADD COMMENTlink modified 7.6 years ago by Istvan Albert ♦♦ 85k • written 7.6 years ago by AndreiR260
gravatar for Istvan Albert
7.6 years ago by
Istvan Albert ♦♦ 85k
University Park, USA
Istvan Albert ♦♦ 85k wrote:

I have yet to read this paper - but that won't keep me from mentioning my personal opinion having seen similarly titled papers many times before.

I think that there is no unified approach that could explain any type of biological phenomena in detail. Life does not follow unified rules, does not want to be parsimonious, does not need to be logical. All it wants/needs is to survive at whatever cost.

ADD COMMENTlink modified 7.6 years ago • written 7.6 years ago by Istvan Albert ♦♦ 85k

Agree. I think more "global" approaches may not answer our questions but maybe brings us more information and directions for better understanding of this complex scenario.

ADD REPLYlink written 7.6 years ago by AndreiR260
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