Just sharing a interesting paper.
"Here we integrate the diverse modes of gene interactions (regulatory, genetic, phosphorylation, signaling, metabolic and physical protein-protein interactions) to create a unified biological network. We then exploit the unique properties of loss-of-function tolerant and essential genes in this unified network to build a computational model that can predict global perturbation caused by deleterious mutations in all genes."
Citation: Khurana E, Fu Y, Chen J, Gerstein M (2013) Interpretation of Genomic Variants Using a Unified Biological Network Approach. PLoS Comput Biol 9(3): e1002886. doi:10.1371/journal.pcbi.1002886 Editor: Andrey Rzhetsky, University of Chicago, United States of America Received: September 26, 2012; Accepted: November 30, 2012; Published: March 7, 2013