Why is there difference FASTA file in an Accession number?
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6 months ago
Trinh • 0

Hi, I have trouble with Uniprot like the attached picture. When I download the fast file in 2 ways (red circles), it is very different. Please let me know why? and which one could use for proteomic annotation? Thank you so much!

Picture

uniprot • 629 views
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Did you do any basic investigation on these two files? for eg. number, ids and length of the sequences. If so, please post them here.

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Thank you very much for your answer!

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Trinh : If an answer was helpful, you should upvote it; if the answer resolved your question, you should mark it as accepted. You can accept more than one if they work.
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6 months ago

The example that you link seems to indicate that you are downloading different files, one link indicates Pan proteome, the other indicates one specific proteome.

The interface could use some work and specificity,

even so, I don't read the above links as indicating that the same data will be provided at both.

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6 months ago

Indeed, as suggested by Istvan Albert above, the first link leads to the Pan proteome, i.e. the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of Candida auris) (https://www.uniprot.org/proteomes/?query=candida+auris&sort=score) as described in https://www.uniprot.org/help/pan_proteomes .

The first link however leads to the set of proteins encoded by the single proteome described in the page, i.e. the Candida auris reference proteome, strain B8441.

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