4.2 years ago by

Fort Collins, CO, USA

Liner regression models how well a set of points approximate to a line. You can certainly use it on anything; your interpretation of what the trend means is the more meaningful part. Just remember that if you find a linear correlation in your data, it actually is an exponential one. Also understand the strengths and weaknesses of the model you're using (look at your residuals, understand how you can interpret goodness of fit, etc.).

For example:

Incremental doses of drug Y vs. log2(fold change) of transcript X

R^2 = 0.99

Might suggest that incremental doses of drug Y correlate with a base 2 exponential response (y = 2^x) in gene expression, not a linear one.