Question: Identification Of Protein Complexes In A List Of Proteins
1
gravatar for Pappu
5.9 years ago by
Pappu1.9k
Pappu1.9k wrote:

I have a set of 2500 uniprot IDs. Now I want to identify if the proteins in my list are actually forming a complex. I found out CURUM database of complexes: http://mips.helmholtz-muenchen.de/genre/proj/corum I am wondering if there is any tool to figure out which complexes are present in my list of proteins (something like DAVID enrichment analysis).

• 2.4k views
ADD COMMENTlink modified 3.7 years ago by Giovanni M Dall'Olio26k • written 5.9 years ago by Pappu1.9k

Did you find any solution? I am confronting the same problem

ADD REPLYlink written 5.3 years ago by Michi940

@Michi did you find any solution ? if so, it would be nice to know it 

ADD REPLYlink written 3.0 years ago by Mo880
0
gravatar for Fidel
5.9 years ago by
Fidel1.9k
Germany
Fidel1.9k wrote:

Besides CORUM the PDB is also a good source for complexes.

ADD COMMENTlink written 5.9 years ago by Fidel1.9k
0
gravatar for Khader Shameer
5.9 years ago by
Manhattan, NY
Khader Shameer17k wrote:

+1 CORUM; If you are interested in curated subset of complexes from human proteome - you can also consult HGNC gene families list. There is a total of 17 curated complex with a total of 263 genes.

Actin related protein 2/3 complex subunits
Anaphase promoting complex subunits
Biogenesis of lysosomal organelles complex-1 subunits
Components of oligomeric golgi complex
Elongator acetyltransferase complex subunits
General transcription factor IIH complex subunits
HAUS augmin-like complex subunits
Histocompatibility complex
INO80 complex subunits
Mitochondrial respiratory chain complex assembly factors
Mitochondrial respiratory chain complex / Complex I
Mitochondrial respiratory chain complex / Complex II
Mitochondrial respiratory chain complex / Complex III
Mitochondrial respiratory chain complex / Complex IV
Mitochondrial respiratory chain complex / Complex V
THO complex subunits
Trafficking protein particle complex
ADD COMMENTlink written 5.9 years ago by Khader Shameer17k
0
gravatar for Giovanni M Dall'Olio
3.7 years ago by
London, UK
Giovanni M Dall'Olio26k wrote:

Protein Complexes are also annotated in Reactome. I don't think there is a tool to do what you want, but you can download the mapping files and parse them to get the proteins associated to any complex.

ADD COMMENTlink written 3.7 years ago by Giovanni M Dall'Olio26k
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