I have a set of 2500 uniprot IDs. Now I want to identify if the proteins in my list are actually forming a complex. I found out CURUM database of complexes: http://mips.helmholtz-muenchen.de/genre/proj/corum I am wondering if there is any tool to figure out which complexes are present in my list of proteins (something like DAVID enrichment analysis).
+1 CORUM; If you are interested in curated subset of complexes from human proteome - you can also consult HGNC gene families list. There is a total of 17 curated complex with a total of 263 genes.
Actin related protein 2/3 complex subunits Anaphase promoting complex subunits Biogenesis of lysosomal organelles complex-1 subunits Components of oligomeric golgi complex Elongator acetyltransferase complex subunits General transcription factor IIH complex subunits HAUS augmin-like complex subunits Histocompatibility complex INO80 complex subunits Mitochondrial respiratory chain complex assembly factors Mitochondrial respiratory chain complex / Complex I Mitochondrial respiratory chain complex / Complex II Mitochondrial respiratory chain complex / Complex III Mitochondrial respiratory chain complex / Complex IV Mitochondrial respiratory chain complex / Complex V THO complex subunits Trafficking protein particle complex
Protein Complexes are also annotated in Reactome. I don't think there is a tool to do what you want, but you can download the mapping files and parse them to get the proteins associated to any complex.