News:Impact of outdated gene annotations on pathway enrichment analysis
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7.7 years ago
pld 5.1k

Pathway enrichment analysis is a common technique for interpreting gene lists derived from high-throughput experiments1. Its success depends on the quality of gene annotations. We analyzed the evolution of pathway knowledge and annotations over the past seven years and found that the use of outdated resources has strongly affected practical genomic analysis and recent literature: 67% of ~3,900 publications we surveyed in 2015 referenced outdated software that captured only 26% of biological processes and pathways identified using current resources.

http://www.nature.com/nmeth/journal/v13/n9/full/nmeth.3963.html

Questions about functional enrichment and pathway tools being out of date seem to show up on Biostars often. Thought this would be of use.

pathway-enrichment gene-ontology david go • 1.8k views
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First published as preprint: http://biorxiv.org/content/early/2016/04/19/049288 (I read it before it was in nature, hipster scientist).

And "coincidentally", a bit later DAVID got finally updated.

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I read it on Biostar before it was even on arxiv - I match your hipster and raise it to a nerd.

C: GO analysis: DAVID vs GREAT vs GOrilla

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A shame that WikiPathways was not included in the analysis :(

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