What are the most important unresolved problems in Bioinformatics?
Is there any problem very important but very chanllenge? Why it's important? And why it's chanllenge? For mathematical difficulty, huge computation, or lack of data?
Genome assembly specially with highly repetitive regions
Writing a specification for the fasta format. :-)
Predicting the protein structure from the sequence of the mRNA or the gene.
Predicting relationship between regions of the genome.
Understand the relationship/interaction between miRNA, siRNA, lncRNA, mRNA, rRNA,....
Simulating a live being from birth to death.
Predict interactions of metabolites, proteins or not.
All encompassing is 'Predicting Phenotype from Genotype or the other way around'.
How to use Excel without getting dates for gene names ;-)
here is a nice article addressing the issue
Combing large datasets from multiple platforms/centers/databases for prediction and inference.
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