Forum: Workstation : More RAM or Faster RAM
0
gravatar for venuraherath
4 days ago by
venuraherath10
venuraherath10 wrote:

Hi Folks,

I am wondering what is more appropriate for the workstations I am building mainly for WGA and RNAseq of Eukaryotic genomes.

  1. 32-64 GB DDR4 RAM (2800 or 3000 MHz) vs 16 GB DDR4 RAM (3600 MHz)

Motherboard is supporting 128 GB max RAM. I will be adding more RAM at one point currently limited by the budget . Above is for the initial configuration.

Processor : AMD Threadripper 1900x Storage : 2X 250 GB NVME and 2 X 1TB SATA III GPU: NVIDIA GTX 1050i

Any other suggestions also greatly appreciated. (I wont be able to use AWS since bandwidth limitations at my University).

Thank you!

ADD COMMENTlink modified 4 days ago by Eli Korvigo130 • written 4 days ago by venuraherath10
1

WGA is whole genome assembly? Unless you are talking small genomes, even 128GB may be too few memory.

Describe in more detail what you will be doing, expected sizes of datasets, organisms you will work.

ADD REPLYlink written 4 days ago by h.mon20k

Part of the skill in using cloud services is finding how to reduce the bandwidth required.

ADD REPLYlink written 4 days ago by karl.stamm3.3k

RamRS may be knowing better.

ADD REPLYlink written 4 days ago by cpad01129.3k

RAM speeds make incredibly negligible differences to overall performance. As others have said: get as much as you can. You'll be bottlenecked by I/O or CPU long before RAM anyway.

ADD REPLYlink written 4 days ago by jrj.healey7.5k
5
gravatar for genomax
4 days ago by
genomax57k
United States
genomax57k wrote:

More RAM period.

There is one thing you can't find a substitute for and that is enough RAM. If you don't have enough you simply won't be able to analyses you want, no matter what speed it is.

ADD COMMENTlink modified 4 days ago • written 4 days ago by genomax57k

If I had enough RAM I would then like faster RAM.

ADD REPLYlink written 4 days ago by karl.stamm3.3k

What's enough RAM though? This week I noticed that 256GB isn't enough RAM for e.g. indexing a large reference with default Bowtie2 settings. Sure I can increase offrate but it goes directly against my aims..

ADD REPLYlink modified 4 days ago • written 4 days ago by 5heikki7.7k
0
gravatar for Eli Korvigo
4 days ago by
Eli Korvigo130
Russian Federation
Eli Korvigo130 wrote:

If you are going to be serious about assembly and RNA-seq, you must get 256GB at the very least. And those RAM clock rates are not important, that is standard 2400 MHz DDR4 modules will do just fine: you will be far more limited by single-core CPU performance, CPU-caches and IO. 2TB of long-term disk storage is not enough, either. You don't need a GPU, unless this machine will be used for machine-learning.

P.S.

Your choice of CPU, RAM and GPU indicates that you want a desktop that will be primarily used for personal stuff (e.g. gaming), which is not particularly compatible with a research-oriented HPC. A research HPC can only generate value, if it is loaded 24/7 with research tasks. These machines use server CPUs, server RAM (ECC) and, as far as deep-learning is concerned, GPUs with large amounts of VRAM. You don't buy these machines for personal use. I believe you should rethink this purchase and find a way to solve your bandwidth issues instead.

ADD COMMENTlink modified 4 days ago • written 4 days ago by Eli Korvigo130
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