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2
votes
6
replies
1.3k
views
Can we get absolute abundance of TCR using TCR-Seq?
TCR-Seq
updated 4 months ago by ▴ 60 • written 4.4 years ago by ▴ 710
1
vote
4
replies
1.6k
views
Shannon vs Simpson for TCR diversity estimation
TCR shannon simpson
updated 4 months ago by ▴ 60 • written 4.1 years ago by ▴ 710
0
votes
1
reply
1.3k
views
Wilcoxon test, t-test and negative binomial test for DEG of scRNA-Seq data
scRNA-Seq DEG differential expression
updated 7 months ago by 12k • written 2.6 years ago by ▴ 710
0
votes
0
replies
540
views
Why case-controlled study is more bias prone than cohort study?
case-controlled study cohort study confounder
written 2.5 years ago by ▴ 710
0
votes
0
replies
191
views
Which distribution to choose for ploting mutant allele frequency?
distribution SNV
7 months ago by CY ▴ 710
0
votes
2
replies
2.6k
views
Comment: Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
12 months ago by CY ▴ 710
0
votes
1
reply
330
views
Reference material for distinguishing focal CNV and chromosome CNV
CNV
updated 17 months ago by ★ 2.9k • written 17 months ago by ▴ 710
0
votes
1
reply
675
views
What is the well-recognized standard of coverage uniformity
sequencing CNV depth uniformity coverage
updated 23 months ago by ★ 2.9k • written 23 months ago by ▴ 710
0
votes
0
replies
898
views
Comment: Comment: Detection of CNV(InDel) of intermediate size
24 months ago by CY ▴ 710
0
votes
1
reply
512
views
Detection of biallelic mutation (inactivation)
somatic biallelic mutation
updated 24 months ago by ▴ 160 • written 24 months ago by ▴ 710
4
votes
2
replies
1.4k
views
Forum: Why did expression based subtypng of breast cancer gain much more acceptance than others
RNA-Seq subtyping expression
updated 2.2 years ago by 129k • written 2.2 years ago by ▴ 710
0
votes
0
replies
450
views
Comment: C: Violation of Independence test for differential methylation (DM)
2.2 years ago by CY ▴ 710
0
votes
2
replies
450
views
Violation of Independence test for differential methylation (DM)
methylation differential methylation
2.2 years ago by CY ▴ 710
3
votes
3
replies
1.0k
views
Treat methylation as binary or continuous signal when detecting DMR?
methylation
2.7 years ago by CY ▴ 710
0
votes
1
reply
1.0k
views
Comment: C: Treat methylation as binary or continuous signal when detecting DMR?
2.7 years ago by CY ▴ 710
0
votes
1
reply
1.9k
views
Comment: C: What statistical test for CpG DMR ?
2.7 years ago by CY ▴ 710
5
votes
1
reply
996
views
Is definition of differentially methylated region (DMR) biologically meaningful?
methylation DMR
updated 2.7 years ago by 2.9k • written 2.7 years ago by ▴ 710
0
votes
2
replies
923
views
Defining methylation level of CpG island
methylation CpG island
2.7 years ago by CY ▴ 710
0
votes
0
replies
923
views
Comment: C: Defining methylation level of CpG island
2.7 years ago by CY ▴ 710
0
votes
1
reply
628
views
Comment: C: How to derive sequence of novel transcript identified by Cufflinks
2.8 years ago by CY ▴ 710
0
votes
3
replies
628
views
How to derive sequence of novel transcript identified by Cufflinks
transcript RNA-Seq
2.8 years ago by CY ▴ 710
0
votes
0
replies
384
views
Did and why recent studies show superior predictive power using methylation data on early cancer detection
methylation cancer detection
2.9 years ago by CY ▴ 710
0
votes
0
replies
543
views
Example code of MCMC on somatic variant calling (site specific error model)
Variant calling
3.0 years ago by CY ▴ 710
0
votes
0
replies
371
views
Create synthetic data based on general description of molecular characteristic for modeling
next-gen
3.1 years ago by CY ▴ 710
0
votes
0
replies
2.6k
views
Comment: Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
3.1 years ago by CY ▴ 710
13
votes
9
replies
2.6k
views
Why NB distribution is preferred in RNA-Seq while normal distribution is preferred in microarray?
RNA-Seq Microarray
updated 12 months ago by ★ 4.2k • written 3.1 years ago by ▴ 710
0
votes
0
replies
756
views
Comment: C: Logit-normal distribution to model variation among biological replicates
3.2 years ago by CY ▴ 710
0
votes
2
replies
756
views
Logit-normal distribution to model variation among biological replicates
rMATS alternative splicing distribution
updated 3.2 years ago by 85k • written 3.2 years ago by ▴ 710
0
votes
1
reply
612
views
How does aligner determine strandness when doing alignment
alignment
3.2 years ago by CY ▴ 710
0
votes
4
replies
843
views
Would curated pathway gene set better being weighted than being binary
RNA-Seq enrichment analysis
updated 3.2 years ago by 20 • written 3.4 years ago by ▴ 710
0
votes
1
reply
647
views
Comment: C: Distinguishing real RNA-editing event from sequencing artifact due to reverse tr
3.2 years ago by CY ▴ 710
0
votes
3
replies
647
views
Distinguishing real RNA-editing event from sequencing artifact due to reverse transcription
RNA-editing sequencing artifact
3.2 years ago by CY ▴ 710
1
vote
2
replies
898
views
Detection of CNV(InDel) of intermediate size
CNV InDel
24 months ago by CY ▴ 710
2
votes
3
replies
730
views
Identifying zygosity of somatic deletion
CNV
updated 3.3 years ago by ▴ 410 • written 3.3 years ago by ▴ 710
0
votes
0
replies
730
views
Comment: C: Identifying zygosity of somatic deletion
3.3 years ago by CY ▴ 710
0
votes
1
reply
755
views
Comment: C: In PCA on RNA-Seq data, what does Gaussian distribution refer to?
3.4 years ago by CY ▴ 710
0
votes
3
replies
755
views
In PCA on RNA-Seq data, what does Gaussian distribution refer to?
RNA-Seq PCA Gaussian
updated 3.4 years ago by 103k • written 3.4 years ago by ▴ 710
0
votes
1
reply
9.4k
views
Comment: C: PCA vs ICA prior to t-SNE or UMAP
3.4 years ago by CY ▴ 710
0
votes
1
reply
9.4k
views
Comment: C: PCA vs ICA prior to t-SNE or UMAP
3.4 years ago by CY ▴ 710
0
votes
2
replies
843
views
Comment: C: Would curated pathway gene set better being weighted than being binary
3.4 years ago by CY ▴ 710
0
votes
0
replies
1.8k
views
Comment: C: bwa XA field: What is the procedure for the binning of all but one alternative a
3.4 years ago by CY ▴ 710
1
vote
1
reply
976
views
Comment: C: Arm-level SCNA does not change mRNA expression level?
3.5 years ago by CY ▴ 710
0
votes
0
replies
734
views
Comment: C: Does variant enrichment analysis make sense?
3.5 years ago by CY ▴ 710
0
votes
2
replies
734
views
Does variant enrichment analysis make sense?
enrichment analysis somatic variant expression
3.5 years ago by CY ▴ 710
6
votes
6
replies
976
views
Arm-level SCNA does not change mRNA expression level?
CNV SCNA expression
3.5 years ago by CY ▴ 710
2
votes
7
replies
948
views
Why can we still be able to continuously discover new cancer driver bioinformatically these days?
driver gene cancer
3.5 years ago by CY ▴ 710
2
votes
0
replies
976
views
Comment: C: Arm-level SCNA does not change mRNA expression level?
3.5 years ago by CY ▴ 710
1
vote
1
reply
976
views
Comment: C: Arm-level SCNA does not change mRNA expression level?
3.5 years ago by CY ▴ 710
0
votes
1
reply
948
views
Comment: C: Why can we still be able to continuously discover new cancer driver bioinformati
3.5 years ago by CY ▴ 710
0
votes
1
reply
948
views
Comment: C: Why can we still be able to continously discover new cancer driver bioinformatic
3.5 years ago by CY ▴ 710
275 results • Page 1 of 6
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